British Journal of Medicine and Medical Research, ISSN: 2231-0614,Vol.: 16, Issue.: 10


The Polymorphism of Regulatory Region of NOS3 Gene (rs2070744, Genotype CC) Protect Patients from Chronic Migraine


Eugene Klimov1,2*, Natalia Kondratieva1, Kirill Skorobogatykh3, Julia Azimova3, Alexey Sergeev3,4, Zarema Kokaeva1, Elena Naumova1,2, Andrey Rachin3,5 and Gyuzyal Tabeeva3,4
1Department of Genetics, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
2University Diagnostic Laboratory, Moscow, Russia.
3University Headache Clinic, Moscow, Russia.
4Department of Neurology, Research Center of the I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
5Department of Neurology, Federal State-Funded Institution, Russian Scientific Center for Medical Rehabilitation and Balneology, Moscow, Russia.

General Comment

1. Up to 6th August 2012, all SDI journals followed strict double-blind review policy to ensure neutral evaluation. During this review process identity of both, the authors and reviewers are kept hidden to ensure the unbiased evaluation. More information is available at this link.


2. We have migrated to transparent and toughest ‘Advanced OPEN peer review’ system (Detailed general information is available at this link). The identity of the authors and reviewers will be revealed to each other during this review process. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers (Example Link). If reviewers do not want to reveal their identities, we will honour that request. In that case, only the review reports will be published as ‘anonymous reviewer report’.


3. Additionally ‘Advanced OPEN peer review’ greatly helps in ‘continuity and advancement of science’. We firmly believe that all the files related to peer review of a manuscript are valuable and hold an important place in the continuity and advancement of science. If publishers publish the peer review reports along with published papers, this process can result in savings of thousands of hours of future authors during experiments, manuscript preparation, etc. by minimising the common errors after reading these previously published peer review reports. Therefore, as per our new official policy update, if the manuscript is published, all peer review reports will be available to the readers. All files (like the original manuscript, comments of the reviewers, revised manuscript, and editorial comment (if any)) related to the peer review, will be available in “Review history” link along with the published paper (Example Link).


4. Additionally, we believe that one of the main objectives of peer review system is ‘to improve the quality of a candidate manuscript’. Normally we try to publish the ‘average marks (out of 10)’ a manuscript received at initial peer review stage and at final publication stage to record its history of improvement during peer review. This process further increases the transparency. It is more important to record the ‘strength and weakness of a manuscript honestly’ than claiming that 'our peer review system is perfect’. Therefore, these transparent processes (i.e. publication of review history files and scores of a particular manuscript) additionally give a clear idea of the strength and weakness of a published paper to the readers. This process enhances the chances of proper use of the result of research (and or reduces the chances of misuse of the weakness of the findings of the paper). Thus this transparent process may prove to be highly beneficial for the society in the long run.


Specific Comment

Average Peer review marks at initial stage: 8.1/10

Average Peer review marks at publication stage: 9/10

Peer review history

Stage Description File 1 File 2
Stage 1 Original Manuscript File 1 NA
Stage 2 Peer review report_1(Syuichi Tetsuka, Japan) File 1 NA
Stage 2 Peer review report_2(Yildiz Degirmenci, Turkey) File 1 NA
Stage 2 Peer review report_3(Jera Kruja, Albania) File 1 NA
Stage 2 Peer review report_4(Robert Perna, USA) File 1 NA
Stage 2 Peer review report_5(Rajendra Nath, India) File 1 NA
Stage 2 Revised MS v1 and Feedback v1 File 1 File 2
Stage 2 Re-Review report_1_v1(Syuichi Tetsuka, Japan) File 1 NA
Stage 2 Re-Review report_2_v1(Yildiz Degirmenci, Turkey) (NA) NA NA
Stage 2 Re-Review report_3_v1(Jera Kruja, Albania) (NA) NA NA
Stage 2 Re-Review report_4_v1(Robert Perna, USA) File 1 NA
Stage 2 Re-Review report_5_v1(Rajendra Nath, India) File 1 NA
Stage 2 Revised MS v2 and Feedback v2 File 1 File 2
Stage 3 Comment_Editor_1_v1 File 1 NA